Stanford Experts Offer Latest Prostate Cancer Information



New Hope for Men With Metastatic Prostate Cancer

Potential Game Changer

The results of a very important research study have just been presented that is likely to completely change the way patients are treated. Men were randomized to receive either the drugs lowering testosterone or a combination of those drugs plus Taxotere. The chemotherapy was given for up to six cycles and the ADT was continued long term. The results were dramatic; the combination significantly improved overall survival: One-half of the men getting the new treatment were alive at 58 months compared to only 44 months with the ADT alone. The difference was 17 months in men with more extensive disease, meaning they had at least four sites of bone metastases or it had spread to other organs. Importantly, the men getting the chemotherapy did not have a high risk of side effects. Fever from a low white blood cell count occurred in only 6 percent of the men, 1 percent experienced significant effects on sensory nerves, and 1 percent on motor nerves.

There are two very important implications from this study. First, it means that all men with newly diagnosed metastatic disease should be referred to an oncologist for a consultation to discuss the chemotherapy because few urologists administer Taxotere and they are not very familiar with the treatment. Secondly, it means that both a urologist and oncologist will be administering treatment simultaneously. Patients should be aware they could request that the oncologist administer both treatments for convenience. If your doctor discovers that you have cancer that has spread, be sure to ask about this new approach as many urologists may not yet be familiar with these findings.

The bottom line is that there is now important evidence that can greatly help men with metastatic prostate cancer. This is in addition to the other new drugs approved in the last few years for men when the ADT is no longer controlling the cancer. These include sipuleucel-t (Provenge), abiraterone (ZYTIGA), enzalutamide (XTANDI), and radium-223 (Xofigo). Furthermore, other new drugs are also being studied that may provide additional help for men with advanced disease.

Last Updated:6/17/2014
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Date: 11.12.2018, 10:15 / Views: 85473