Diffuse toxic goiter

Diffuse toxic goiter: symptoms


The basis of the pathogenesis of the disease may be a violation of immune surveillance, in which the formation of autoantibodies with a stimulating effect occurs, which inevitably leads to hyperfunction of the thyroid gland with subsequent hyperplasia and hypertrophy. In addition, hereditary factors, chronic infections, intoxications, and psychological trauma are of great importance.


The main symptoms of diffuse toxic goiter:



  • Crying;

  • Irritability;

  • Frequent mood swings;

  • Excitability;

  • Hand tremor;

  • Insomnia;

  • Increased fatigue;

  • Weight loss with increased appetite;

  • Tachycardia;

  • Atrial fibrillation;

  • Dyspepsia;

  • Disruption of the gastrointestinal tract;

  • Amyotrophy;

  • Pretibial myxadema when skin thickening occurs on the front side of the feet and lower leg;

  • Decreased potency;

  • Violation of the menstrual cycle;

  • Gynecomastia.


It should be noted, not always in the presence of diffuse toxic goiter weight loss occurs.Some patients gain a sufficient amount of extra pounds, and Basedow's disease proceeds against the background of obesity.


Diagnosis of diffuse toxic goiter


Referral to the examination gives the doctor endocrinologist. Ultrasound shows that the thyroid gland has a diffuse increase, exophthalmos is observed from the eyes without trophic disorders. When looking down, the upper eyelids lag behind the movements of the eyeball. Neurological examination of the patient reveals the instability of the position of Romberg, hyperreflexia.


The blood test shows a significant reduction in cholesterol, elevated iodine, low levels of triiodothyronine, thyroxine, and thyrotropic hormone. In any doubtful situation, when making an accurate diagnosis is questionable, the patient is prescribed tests with tyroliberin.


If the level of thyroid stimulating hormone does not increase during testing, the toxic diffuse goiter is considered confirmed.


Treatment of diffuse toxic goiter


Drug or surgical methods are used as treatment. The doctor selects an effective dose of thyrostatistical drugs, prescribes radioactive iodine.



Date: 09.10.2018, 23:01 / Views: 94373

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