Biochemical screening: to do or not

What is biochemical screening?


As the fetus develops, the placenta begins to release special substances into the blood of the expectant mother. Biochemical analysis is aimed at the study of these substances. Deviation from the norm may indicate that pregnancy is not proceeding smoothly. Prescribe screening twice during the entire period of pregnancy. The first examination takes place in the first trimester at 10-14 weeks, and the second at 16-20 weeks.

Is biochemical analysis necessary?


Experts recommend doing this analysis without fail. Because no woman is immune from the development of pathologies in her baby. This is due to the hereditary factor, lifestyle, environmental conditions. The World Health Organization, in turn, recommends that screening be conducted at least in the second trimester. Each expectant mother has the right to decide for herself whether to conduct an analysis or not, but once again she can’t be safe. This will help to avoid further problems.

Risk group


Women at risk doctors prescribe screening twice. This group includes: women over 35 years old; women with genetic abnormalities in the family; future mothers who have had an infectious disease in early pregnancy; in case the mother and father are close relatives; if a woman previously had a miscarriage, stillbirth, giving birth to a child with pathologies.

Screening in the first and second trimester


Biochemical screening in the first trimester reveals two substances: hCG, PAPP-A. Doctors determine the amount of each of the substances in the body of the future mother and check if there are any deviations from the norm. If a specialist suspected abnormalities in the development of the embryo, then an ultrasound scan is prescribed. A single analysis gives a reliable prognosis in 60% of cases, but in conjunction with ultrasound the percentage increases to 80. Screening in the first trimester makes it possible to identify Down syndrome and Edwards syndrome.
In the second trimester, three substances are detected during the analysis: hCG, AFP, NE. At a later date, the following anomalies in the development of the fetus can be identified: a malformation of the neural tube, anomaly of the kidneys, a fusion of the abdominal wall.
The following factors may affect the biochemical screening result: multiple pregnancies, IVF, bad habits of the mother (especially smoking), the presence of serious diseases (cold, diabetes). Indicators will depend even on the weight of the woman. Thin-skinned ones are understated, in full ones it is the opposite.

Date: 10.10.2018, 14:05 / Views: 82132

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